With the integration of a Positive Pressure Unit (PPU) into the Biomek i-Series Automated Workstation, we expand the capabilities of automated sample processing to include a key element for modern analytical and life science workflows.
The Positive Pressure technology enables a uniform and precisely controlled application of pressure across all wells of a filtration or solid phase extraction (SPE) plate. This ensures highly reproducible liquid transfer, independent of sample viscosity, matrix complexity, or particulate load. In contrast to vacuum-based approaches, positive pressure elution provides a more stable and consistent flow profile, reducing the risk of channeling and improving overall process uniformity.
By combining the PPU with the flexibility of the Biomek i-Series platform, SPE and filtration steps can be seamlessly integrated into fully automated workflows. This opens up a wide range of applications, including sample cleanup, matrix reduction, analyte concentration, and the preparation of complex biological samples for downstream analytical techniques such as LC-MS or other high-throughput assays.
The accompanying video demonstrates the integration of the Positive Pressure Unit into an automated workflow on the Biomek i3 system. It illustrates typical process steps for SPE and filtration applications and highlights how manual interventions can be replaced by a robust, reproducible, and scalable automated solution.
Overall, the combination of liquid handling automation and Positive Pressure technology enhances laboratory efficiency, improves reproducibility, and increases process reliability in demanding analytical applications.
